From a technical aspect, it is definitely possible. But what about the conceptual? The modder StalkerBlade is exactly doing that at the moment. For various reasons a release isn't planned at the moment but I really hope that he is revising his decision. What I can see so far looks very interesting and promising and with some help from the community chances are high that this turns into a really good thing. Don't believe me? Check the thread and see for yourself - and let's hope, we will get something playable in the near and not so far future.
Mario64 in GZDoom?
